DIPG-25. Patterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma: a report from the International Diffuse Intrinsic Pontine Glioma Registry
| Autor: | Tabitha Cooney, Mariko DeWire-Schottmiller, Adam Lane, Raya Saab, Pratiti Bandopadhayay, Kathleen Dorris, Roger Packer, Lindsay Kilburn, Jane Minturn, Andrew Dodgshun, Sara Parkin, Stewart Goldman, Eric Sandler, Robert Greiner, Nicholas Gottardo, Hetal Dholaria, Scott Coven, Tim Hassall, Jordan Hansford, Yvan Samson, Sarah Leary, Ute Bartels, Adriana Fonseca, Eric Bouffet, Christopher Tinkle, Michelle Monje, Paul Fisher, David Ziegler, Murali Chintagumpala, Lars Wagner, Carl Koschmann, James Leach, Blaise Jones, Elisa Carrasquedo Benito, Hailey Bond, Brooklyn Chaney, Katie Black, Anthony Asher, Maryam Fouladi, Lindsey Hoffman, Katherine Warren |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Neuro-Oncology. 24:i23-i24 |
| ISSN: | 1523-5866 1522-8517 |
| Popis: | BACKGROUND: There are no standard practice guidelines for cerebrospinal (CSF) diversion for diffuse intrinsic pontine glioma (DIPG), nor clear understanding of potential for palliation and life-prolongation. We evaluated CSF diversion characteristics in children with DIPG to determine incidence, indications, symptom effects, and survival. METHODS: Data were extracted from subjects registered in the International DIPG registry (IDIPGR). Univariable analyses was performed using the Fisher’s exact test or Wilcoxon rank sum test. Survival was estimated using the Kaplan-Meier method. RESULTS: Evaluable patients (n=542) met criteria for DIPG diagnosis by central radiologic review; of those, 126 (23%) had permanent CSF diversion. Median time from diagnosis to diversion was 0.5 months (IQR 0.1-4.5 months). Those with permanent diversion were significantly younger (median 5.4 years vs 7.0 years, p |
| Databáze: | OpenAIRE |
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