Anti-inflammatory and anticancer activities of erythrodiol-3-acetate and 2,4-di-tert-butylphenol isolated from Humboldtia unijuga
| Autor: | Devi Velayudhan Jayasree, Reshma Vijayakumari Raveendran Nair, P. G. Biju, Sabulal Baby |
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| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Chemistry medicine.drug_class Aché Organic Chemistry Plant Science Pharmacology 01 natural sciences Biochemistry Caspase 7 Anti-inflammatory language.human_language 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Apoptosis Cell culture Gene expression medicine language Tumor necrosis factor alpha Gene |
| Zdroj: | Natural Product Research. 34:2319-2322 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2018.1531406 |
| Popis: | Humboldtia unijuga Bedd., endemic to Agasthyamala in Western Ghats in India, is traditionally used by local Kani tribes for chicken pox, head ache and snake bite. This study reports the isolation of erythrodiol-3-acetate (HU-1) and 2,4-di-tert-butylphenol (HU-2) from H. unijuga roots and their anti-inflammatory and anticancer activities in macrophage, skin and breast cancer cell lines. Effects of HU-1 and HU-2 treatments (50, 100 µg/mL) on gene expression profiles of pro-inflammatory cytokines TNFα, IL-6 and IL-1β, and apoptosis genes p53 and caspase 7 were studied. HU-2 exerted a significantly superior anti-inflammatory effect compared to HU-1 in all three pro-inflammatory genes. HU-2 showed a superior dose dependent anticancer effect through activation of p53 gene over HU-1 in MCF-7 cells. HU-1 exhibited a dose dependent effect on caspase 7 gene in both cell lines while HU-2 was more effective in A431. HU-2 has potential for development as a novel anti-inflammatory and anticancer agent. |
| Databáze: | OpenAIRE |
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