Restrictions in time and space - new insights into generation of specific neuronal subtypes in the adult mammalian brain

Autor:	Franziska Weinandy, Magdalena Götz, Jovica Ninkovic
Rok vydání:	2011
Předmět:	medicine.anatomical_structure nervous system General Neuroscience Neurogenesis medicine Neuron Cell lineage Biology Mammalian brain Neuroscience Neural stem cell
Zdroj:	European Journal of Neuroscience. 33:1045-1054
ISSN:	0953-816X
DOI:	10.1111/j.1460-9568.2011.07602.x
Popis:	Key questions in regard to neuronal repair strategies are which cells are best suited to regenerate specific neuronal subtypes and how much of a neuronal circuit needs to persist in order to allow its functional repair. Here we discuss recent findings in the field of adult neurogenesis, which shed new light on these questions. Neural stem cells in the adult brain generate very distinct types of neurons depending on their regional and temporal specification. Moreover, distinct brain regions differ in the mode of neuron addition in adult neurogenesis, suggesting that different brain circuits may be able to cope differently with the incorporation of new neurons. These new insights are then considered in regard to the choice of cells with the appropriate region-specific identity for repair strategies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae9705b94474547a95afc02575ea6cf6 https://doi.org/10.1111/j.1460-9568.2011.07602.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.