Synthesis of two 6′α-fluorocarbocyclic nucleosides and incorporation into short segments of DNA

Autor:	Stanley M. Roberts, Andrew N. Payne
Rok vydání:	1992
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Deoxyribonucleotide Ketone chemistry Bicyclic molecule Cyclitol Oligonucleotide Stereochemistry Yield (chemistry) Nucleoside DNA
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :2633-2641
ISSN:	1364-5463 0300-922X
Popis:	The 6′-fluorocarbocyclic nucleosides 1 and 2 have been synthesized from the bicyclic ketone 3 in 16 and 2% yield respectively. The nucleoside 1 has been incorporated into short chains of DNA using an automated synthesizer and these oligonucleotides have been shown to hybridize with (fluorine containing) complementary strands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae8e9031fc37eddb0ca5ead6a9cd1ecf https://doi.org/10.1039/p19920002633 Zobrazit plný text záznamu