ChemInform Abstract: Carboxylate-Directed Cross-Coupling Reactions in the Synthesis of Trisubstituted Benzoic Acids

Autor:	Ioannis N. Houpis, Changkang Huang, Jason G. Chen, Martine Canters, Ulrike Nettekoven, Renmao Liu
Rok vydání:	2009
Předmět:	Solvent chemistry.chemical_classification chemistry.chemical_compound chemistry Base (chemistry) Yield (chemistry) General Medicine Carboxylate Selectivity Appropriate use Combinatorial chemistry Phosphine Coupling reaction
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
Popis:	The carboxylate anion has been used as a directing group to effect selective ortho-substituted derivatives 3 (>99:1 selectivity 50−80% yield). The solvent, base, and equivalents of base are the determining factors for the success of this reaction. The directing effect can be reversed by the appropriate use of phosphine ligands to prepare the para-substituted 4 selectively (ca. 12:1 selectivity).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae8a21c30bc7976ffc37deecb445cbe7 https://doi.org/10.1002/chin.200917098 Zobrazit plný text záznamu Plný text