THE EFFECTS OF PARATHYROID HORMONE ON SERUM GLYCOPROTEIN AND SEROMUCOID LEVELS AND ON THE KIDNEY OF THE RAT1

Autor:	R. Palmer Howard, Claiborne L. Courtright, M. R. Shetlar, Walter Joel, Edward C. Reifenstein
Rok vydání:	1956
Předmět:	chemistry.chemical_classification medicine.medical_specialty Kidney biology Tryptophan Parathyroid hormone Orosomucoid Biuret test Endocrinology medicine.anatomical_structure chemistry Pepsin Internal medicine biology.protein medicine Hexose Glycoprotein
Zdroj:	Endocrinology. 59:532-539
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-59-5-532
Popis:	AN ELEVATION of seromucoid in rats following the administration of parathyroid extracts has been reported by En gel (1), who postulated that this elevation was due to changes of bone matrix. Shetlar, Howard, and Reifenstein (2) in a preliminary report noted that elevations of seromucoid occurred in rats treated with parathyroid extract inactivated by formaldehyde treatment. This work has been extended to more complete studies of serum glycoprotein and seromucoid levels of rats after treatment with active parathyroid extracts and with extracts inactivated by both pepsin and formaldehyde. EXPERIMENTAL Serum glycoprotein was determined b}r the tryptophan method of Shetlar, Foster, and Everett (3), seromucoid hexose by the tryptophan method after isolation by the method of Winzler and Smyth (4), and serum protein by the biuret reaction.
Databáze:	OpenAIRE
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