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OBJECTIVE: Th is study aims to determine the profi le of infl ammatory proteins in unstimulated whole saliva of periodontal patients with or without type 2 diabetes two months aft er non-surgical periodontal therapy. METHODS: Fift y-six patients were enrolled: PD group with 21 patients, PD + DM group with 20 patients and control group with 15 patients. Clinical examination and glycated hemoglobin (HbA1c) measurement were performed before and two months aft er periodontal therapy. Saliva samples were collected to assess 39 salivary proteins using Multiplex Cytokine Profi ling Assay. RESULTS: Th ere were signifi cant reduction two months aft er periodontal therapy for salivary levels of interleukin (IL)-1β, IL-17, IL-10, eotaxin, and monocyte chemoattractant protein (MCP)-3 in PD group, and for salivary levels of IL-1ra, IL-10 and transforming growth factor-alpha (TGF-α) in PD+DM group. Clinical parameters improved signifi – cantly aft er periodontal therapy in both diseased groups, and HbA1c levels in PD+DM group (p |
