A STUDY OF LIPID PROFILE AND ASSESSMENT OF CARDIOVASCULAR RISK IN SUBCLINICAL HYPOTHYROIDISM
| Autor: | Prakash Subramanian, Kishore Chander Prem Kumar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.diagnostic_test business.industry Significant difference 030206 dentistry Newly diagnosed medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Risk index medicine Euthyroid 030212 general & internal medicine Lipid profile business Risk assessment hormones hormone substitutes and hormone antagonists Dyslipidemia Subclinical infection |
| Zdroj: | Journal of Evolution of Medical and Dental Sciences. 8:1318-1320 |
| ISSN: | 2278-4802 2278-4748 |
| Popis: | Background: The studies on association between subclinical hypothyroidism and lipid profile have produced conflicting results. The assessment of cardiovascular risk skin subclinical hypothyroid patients are rare in Indian scenario. Aim: To study the lipid profile in subclinical hypothyroid patients and to assess the cardiovascular risk in subclinical hypothyroid patients by using atherogenic indexes. Materials and Methods: In this case - control study newly diagnosed untreated subclinical hypothyroid patients were studied for dyslipidemia and cardiovascular risk is assessed using lipid ratios Athrogenic index of Plasma and Castelli risk index- I and II compared to euthyroid subjects. To find the significant difference between the bivariate samples in Independent groups the Unpaired sample t-test was used and to find the significance in categorical data Chi-Square test and Fisher's Exact was used. In all the above statistical tools the probability value .05 was considered as significant level. Results: Total cholesterol ,triglyceride and VLDL-C levels shows statistically significant association among subclinical hypothyroid patients compared to euthyroid subjects. Castelli risk index-II showed statistically significant association in subclinical hypothyroid patients compared to euthyroid controls. Conclusion: The positive association of subclinical hypothyroid patients and dyslipidemia warrants that all patients with subclinical hypothyroidism should be evaluated for deranged lipid profile paramaters. Castelli risk index-II calculated as LDL-C/HDL-C could be used as a better predictor of cardiovascular risk compared to the other risk assessment ratios Atherogenic index of plasma and Castelli risk index I. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|