Photo-Promoted Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β,γ-Unsaturated Nitriles
Autor: | Keyang Zhang, Chunxiang Pan, Yuanbin Zhu, Kangkui Li, Shiyuan Wu, Baomin Fan, Chunhui Yang, Yongyun Zhou |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Organic Letters. 23:7188-7193 |
ISSN: | 1523-7052 1523-7060 |
Popis: | An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with K2CO3 and water at room temperature. The methodology worked for a wide range of substrates (22 examples) with up to 83% yield. The protocol is also compatible for gram-scale synthesis. |
Databáze: | OpenAIRE |
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