Photo-Promoted Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β,γ-Unsaturated Nitriles

Autor:	Keyang Zhang, Chunxiang Pan, Yuanbin Zhu, Kangkui Li, Shiyuan Wu, Baomin Fan, Chunhui Yang, Yongyun Zhou
Rok vydání:	2021
Předmět:	Chemistry Yield (chemistry) Organic Chemistry Organic chemistry Physical and Theoretical Chemistry Alkylation Biochemistry Catalysis
Zdroj:	Organic Letters. 23:7188-7193
ISSN:	1523-7052 1523-7060
Popis:	An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with K2CO3 and water at room temperature. The methodology worked for a wide range of substrates (22 examples) with up to 83% yield. The protocol is also compatible for gram-scale synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae70b3466b7c266a9054759b423dcfa9 https://doi.org/10.1021/acs.orglett.1c02585 Zobrazit plný text záznamu