Synthesis of novel fluorescent styryl dyes based on the imidazo[1,2-a]pyridinium chromophore and their spectral-fluorescent properties in the presence of nucleic acids and proteins

Autor:	D. V. Kryvorotenko, Vladyslava B. Kovalska, V. P. Tokar, A. O. Balanda, M. Yu. Losytskyy, Sergiy M. Yarmoluk
Rok vydání:	2006
Předmět:	chemistry.chemical_classification Chemistry Process Chemistry and Technology General Chemical Engineering Iodide Chromophore Ring (chemistry) Combinatorial chemistry Fluorescence Chemical synthesis chemistry.chemical_compound Nucleic acid Organic chemistry Pyridinium DNA
Zdroj:	Dyes and Pigments. 68:39-45
ISSN:	0143-7208
DOI:	10.1016/j.dyepig.2004.12.010
Popis:	The imidazo[1,2-a]pyridinium heterocyclic system was used to prepare styryl dyes. Improved synthetic methods were proposed for the parent imidazo[1,2-a]pyridines and their corresponding quaternary salts. The standard method for preparing styrylcyanines was modified for the synthesis of the target imidazo[1,2-a]pyridinium dyes. Spectral-luminescent properties of the obtained dyes in free state and in the presence of nucleic acids, BSA, and BSA/detergent system were studied. 7-[2-(4-Dihexylaminophenyl)-1-ethenyl]-2-(2,4-dimethoxyphenyl)-1-ethylimidazo[1,2-a]pyridin-1-ium iodide (SIP-8) containing C6 aliphatic tails and 2,4-methoxy substituents in the 2-phenyl ring exhibited specificity to BSA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae6598e30fa33385bc35809cff59c4db https://doi.org/10.1016/j.dyepig.2004.12.010 Zobrazit plný text záznamu Full Text from ScienceDirect