Non-Enzymatic Rearrangement of Leukotriene A4 to 5-Keto-(7E,9E,11Z,14Z)-Eicosatetraenoic Acid in Aqueous Media

Autor:	Jean-Pierre Falgueyret, Laird A. Trimble, J. Yergey, Denis Riendeau, J. Gravel
Rok vydání:	1997
Předmět:	chemistry.chemical_compound Hydrolysis Aqueous solution Chemistry Leukotriene B4 Enzymatic hydrolysis Eicosatetraenoic acid Leukotriene A4 Substrate (chemistry) Glutathione Medicinal chemistry
Zdroj:	Advances in Experimental Medicine and Biology ISBN: 9781461374305
DOI:	10.1007/978-1-4615-5325-0_10
Popis:	Leukotriene A4 (LTA4) is a product of the 5-lipoxygenase reaction and a key intermediate in the biosynthesis of leukotrienes. LTA4 serves as a substrate for the enzymatic hydrolysis to leukotriene B4 or conjugation with glutathione to yield the peptidoleukotrienes. In addition, LTA4 undergoes a rapid non-enzymatic hydrolysis in aqueous solution at neutral pH with a half-time of few seconds. The hydrolysis products have been identified fifteen years ago and shown to correspond mainly to an equimolar mixture of 6-trans-LTB4 and 6-trans-12-epi-LTB4 with smaller amounts of 5,6-dihydroxyeicosatetraenoic acids (5,6-diHETE) (1,2).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae6263c90dc530cc5f4cb20257cef45c https://doi.org/10.1007/978-1-4615-5325-0_10 Zobrazit plný text záznamu