Characterization of a soluble suppressor of human B cell function produced by a continuous human suppressor T cell line. II. Evidence for suppression through a direct action of CTC-SISS-B on human B cells
| Autor: | W C Greene, T A Fleisher, J M Depper, W J Leonard, G J Stanton, T A Waldmann |
|---|---|
| Rok vydání: | 1982 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 129:1120-1123 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.129.3.1120 |
| Popis: | CTC-SISS-B is an antigen-nonspecific suppressive lymphokine elaborated by an interleukin 2-dependent suppressor T cell line that produces noncytotoxic inhibition of human B cell but not T cell function. Like SISS-B, a soluble suppressive lymphokine present in the supernatants of Con A-activated peripheral blood T cell cultures, CTC-SISS-B is of 60,000 to 90,000 m.w., and its action is blocked by the simple sugar L-rhamnose. CTC-SISS-B inhibits human B cell Ig production and proliferation through a direct interaction with human B cells rather than through indirect effects on immunoregulatory T cells or monocytes. CTC-SISS-B suppression occurs through inhibition of an early event(s) in B cell activation since proliferation and Ig production by established human B cell lines are not inhibited by this lymphokine. Despite sharing many biochemical and biologic properties, CTC-SISS-B and gamma-interferon appear to be distinct mediators. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|