Pseudohypoparathyroidism 1942–1966
| Autor: | John-Fredrik Dymling, Carlos A. Mautalen, Melvin Horwith |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Vitamin D metabolism business.industry Parathyroid hormone General Medicine medicine.disease Pathophysiology Excretion Hydroxyproline chemistry.chemical_compound Endocrinology chemistry Internal medicine Calcium infusion Vitamin D and neurology medicine business Pseudohypoparathyroidism |
| Zdroj: | The American Journal of Medicine. 42:977-985 |
| ISSN: | 0002-9343 |
| Popis: | Pseudohypoparathyroidism is described in a forty-two year old white man. The effects of prolonged calcium infusion, short-term and long-term administration of purified bovine parathyroid hormone and treatment with vitamin D were evaluated. Studies of bone mineral metabolism with 47 Ca, vitamin D metabolism with tritiated vitamin D and hydroxyproline excretion were performed. The collected data support the pathophysiologic concept of relative end-organ refractoriness to the action of parathyroid hormone as the basic mechanism. In this patient a transition was noted, not previously described, from hypocalcemia to eucalcemia, maintained over a period of more than six years, to hypocalcemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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