Prelimbic α1-adrenoceptors are involved in the regulation of depressive-like behaviors in the hemiparkinsonian rats
| Autor: | Wen Juan Li, Qiao Jun Zhang, Cheng Xue Du, Ya Xin Yang, Fang Yuan Guo, Jian Liu, Zhong Heng Wu, Yue Xi, Shu Qi Yu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Chemistry General Neuroscience Infralimbic cortex Dopaminergic Hippocampus 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Monoamine neurotransmitter Endocrinology nervous system Dopamine Internal medicine medicine Medial forebrain bundle Benoxathian Phenylephrine 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain Research Bulletin. 134:99-108 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2017.07.011 |
| Popis: | At present, it is not clear whether α1-adrenoceptors in the prelimbic cortex (PrL) are involved in Parkinson's disease-related depression. Here we examined effects of PrL α1-adrenoceptors on depressive-like behaviors in rats with unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. The lesion induced depressive-like responses as measured by the sucrose preference and forced swim tests compared to sham-operated rats. Intra-PrL injection of α1-adrenoceptor agonist phenylephrine induced or increased the expression of depressive-like behaviors in sham-operated and the lesioned rats. Further, intra-PrL injection of α1-adrenoceptor antagonist benoxathian produced antidepressant effects in two groups of rats. Intra-PrL injection of phenylephrine increased the mean firing rate of PrL pyramidal neurons in both sham-operated and the lesioned rats, while benoxathian decreased the mean firing rate of the neurons. Compared to sham-operated rats, the duration of phenylephrine and benoxathian action on the firing rate of the pyramidal neurons was shortened in the lesioned rats. Neurochemical results showed that intra-PrL injection of phenylephrine or benoxathian increased or decreased dopamine and noradrenaline and serotonin levels in the medial prefrontal cortex, ventral hippocampus and habenula in sham-operated and the lesioned rats, respectively. Altogether, these results suggest that activation and blockade of α1-adrenoceptors in the PrL change the firing activity of the pyramidal neurons, and then increase or decrease levels of three monoamines in the limbic and limbic-related brain regions, which are involved in the regulation of depressive-like behaviors. Additionally, the results also suggest that the dopaminergic lesion leads to hypofunctionality of α1-adrenoceptors on pyramidal neurons of the PrL. |
| Databáze: | OpenAIRE |
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