Searching for enhanced iron fortification of formula milk via nanoparticles and Isotope Pattern Deconvolution
| Autor: | Alfredo Sanz-Medel, María Luisa Fernández-Sánchez, Belén Fernández-Colomer, Rafaella Regina Alves Peixoto, Marta Costa Romero, Sonia Fernández-Menéndez |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Ferrous sulphate Isotope Chemistry Iron levels Nanoparticle Iron fortification 02 engineering and technology Absorption (skin) 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics Analytical Chemistry Body iron 03 medical and health sciences 030104 developmental biology Iron content Food science 0210 nano-technology Instrumentation Spectroscopy |
| Zdroj: | Spectrochimica Acta Part B: Atomic Spectroscopy. 148:165-171 |
| ISSN: | 0584-8547 |
| DOI: | 10.1016/j.sab.2018.06.017 |
| Popis: | Nanoparticles (NPs) of 57Fe(III) oxo-hydroxide have been investigated for formula milk iron fortification. The body iron status of lactating rats was evaluated by analyzing iron content in all iron compartments (functional, transport and storage). Results were compared with a non‑iron fortified rat group (NF) and a rat group fortified with FeSO4. Intestinal iron (57Fe) absorption observed in rats using the synthesized NPs was 91% (similar to the obtained for FeSO4), and their total iron levels in the functional compartment were the highest, while similar values were observed in the other iron compartments for both iron fortified groups. Exogenous 57Fe incorporation from NPs was always higher than 56% in all the analyzed iron compartments. Interestingly, higher than those observed for other physicochemical forms assayed for formula milk fortification. This work has shown that 57Fe from the assayed NPs is efficiently incorporated keeping appropriate iron levels, protecting from possible body iron deficiency. |
| Databáze: | OpenAIRE |
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