New brain metastases after whole-brain radiotherapy of initial brain metastases in breast cancer patients: the significance of molecular subtypes (KROG 16-12)

Autor: Jinhee Kim, Woong Ki Chung, Wonguen Jung, Seock-Ah Im, Tae Hyun Kim, Jeanny Kwon, In Ah Kim, Jae Sik Kim, Ki Mun Kang, Byung Ock Choi, Sea Won Lee, Kyung Hwan Shin, Yong Bae Kim, Won Sup Yoon, Hee Jun Kim, Kyung Su Kim, Kyubo Kim, Suzy Kim, Jee Suk Chang, Yeon Hee Park, Jihye Cha, Dae Yong Kim, Yoon Kyeong Oh, Jee Hyun Kim, Doo Ho Choi
Rok vydání: 2021
Předmět:
Zdroj: Breast Cancer Research and Treatment. 186:453-462
ISSN: 1573-7217
0167-6806
DOI: 10.1007/s10549-020-06043-0
Popis: To identify the risk factors leading to new brain metastases (BM) following brain-directed treatment for initial BM resulting from breast cancer (BC). In this multi-institutional study, 538 BC patients with available follow-up imaging after brain-directed treatment for initial BM were analyzed. Tumor molecular subtypes were classified as follows: hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−, n = 136), HER2-positive (HER2+, n = 253), or triple-negative BC (TNBC, n = 149). In 37.4% of patients, new BM emerged at a median of 10.5 months after brain-directed treatment for initial BM. The 1-year actuarial rate of new BM for HR+/HER2−, HER2+, and TNBC were 51.9%, 44.0%, and 69.6%, respectively (p = 0.008). Initial whole-brain radiotherapy (WBRT) reduced new BM rates (22.5% reduction at 1 year, p 4) (p
Databáze: OpenAIRE
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