Chemical Characterization of Bioactive Components ofRosa caninaExtract and Its Protective Effect on Dextran Sulfate Sodium-Induced Intestinal Bowel Disease in a Mouse Model
| Autor: | Nacim Zouari, Hichem Sebai, Mourad Jridi, Kais Rtibi, Najla Hajji, Dalanda Wanes, Afifa Abdellaoui, Mohamed-Amine Jabri, Haifa Tounsi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Nutrition and Dietetics biology Chemistry Rosa canina Medicine (miscellaneous) chemistry.chemical_element Inflammation Pharmacology Calcium medicine.disease medicine.disease_cause biology.organism_classification 03 medical and health sciences Diarrhea 0302 clinical medicine Sulfasalazine 030220 oncology & carcinogenesis medicine medicine.symptom Colitis Gastritis Oxidative stress medicine.drug |
| Zdroj: | Journal of Medicinal Food. 23:1109-1119 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | Rosa canina is a well-known medicinal plant used in folk remedy that alleviates various disorders, including inflammation, gastritis, and diarrhea. The objective of this investigation was to identify and quantify the phenolic components of R. canina methanolic extract (RCME) and to determine its protective action with dextran sulfate sodium (DSS)-generated mice colitis model. RCME chemical analysis was done using Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry, and experimental animals received RCME at different doses before colitis induction by oral DSS administration during 7 days. Another group received sulfasalazine as a positive control. Colitis damages and RCME benefits were assessed using histopathological and biochemical changes and improvements. Many phenolic compounds have been identified. In addition, the DSS intoxication induced an alteration of colonic epithelium associated with an oxidative stress state. DSS administration led to an increase or decrease of intracellular mediators such as free iron and ionizable calcium. RCME consumption effectively protected against colonic histological/biochemical alterations induced by DSS intoxication providing support for the traditional use of this plant. |
| Databáze: | OpenAIRE |
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