Microwave promoted reaction of purin-6-yl magnesium halides with aldehydes in dichloromethane at 100 °C
| Autor: | Stephen D. Lindell, Malcolm R. Gordon |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Magnesium Organic Chemistry chemistry.chemical_element Halide 010402 general chemistry 01 natural sciences Biochemistry Aldehyde 0104 chemical sciences chemistry.chemical_compound Ethylmagnesium bromide chemistry Yield (chemistry) Drug Discovery Microwave Nuclear chemistry Dichloromethane |
| Zdroj: | Tetrahedron Letters. 59:1945-1947 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2018.04.014 |
| Popis: | Treatment of a dichloromethane solution of 9-benzyl or 9-phenyl 6-iodopurine with ethereal ethylmagnesium bromide at ambient temperature gives the corresponding purin-6-yl magnesium halides. Addition of an aldehyde followed by heating at 100 °C in a microwave reactor yielded the corresponding carbinols in 52–81% yield. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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