Six New Lanostane Triterpenoids from the Fruiting Body of Tyromyces Sambuceus and Antiproliferative Activity
| Autor: | Mina Okazoe, Toshihiro Hashimoto, Joji Takahashi, Masaaki Noji, Hirosi Imagawa, Kazuko Yoshikawa, Akemi Umeyama, Kanako Iseki, Naoki Kokudo |
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| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
010405 organic chemistry Stereochemistry Hydroxy group Plant Science General Medicine 01 natural sciences Lanostane Nmr data Tyromyces sambuceus 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Triterpenoid Complementary and alternative medicine chemistry Drug Discovery Human cancer |
| Zdroj: | Natural Product Communications. 11:1934578X1601100 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1601100208 |
| Popis: | During the search for secondary metabolites with antiproliferative activity, six new lanostane triterpenoids, tyrosamic acids A-F (1–6) together with ten known compounds (7–16), were isolated from the fruiting body of Tyromyces sambuceus. Their structures were elucidated using MS analyses, extensive 2D-heteronuclear NMR data interpretation and the structure of 3 was further confirmed by single-crystal X-ray data analyses. All lanostane triterpenoids (1–16) possesses a carboxy group at C-20 position and their strength of antiproliferative activity was affected by the presence or absence of a hydroxy group at C-15 position and at the side chain. Four of the compounds (1, 6, 10, 14) showed antiproliferative activities against human cancer cell lines with IC50 values of 16.8–48.3 μM (HL-60). |
| Databáze: | OpenAIRE |
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