Ground- and excited-state interactions of 2,7,12,17-tetraphenylporphycene with model target biomolecules for type-I photodynamic therapy

Autor:	M. Lluïsa Sagristá, Santi Nonell, Noemí Rubio, Margarita Mora, José I. Borrell, Jordi Estruga, Víctor Martínez-Junza
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Chemistry Singlet oxygen Biomolecule medicine.medical_treatment Photodynamic therapy General Chemistry Photochemistry chemistry.chemical_compound Electron transfer Mechanism of action Excited state Gramicidin medicine Photosensitizer medicine.symptom
Zdroj:	Journal of Porphyrins and Phthalocyanines. 13:99-106
ISSN:	1099-1409 1088-4246
DOI:	10.1142/s1088424609000103
Popis:	Biosubstrate-sensitizer binding is one of the factors that enhances the type-I mechanism over the type-II in the whole photodynamic process. 2,7,12,17-Tetraphenylporphycene (TPPo), a second-generation photosensitizer, is a hydrophobic compound with good photophysical properties for photodynamic therapy applications that has proved its ability for the photoinactivation of different cell lines. Nevertheless, little is known about its mechanism of action. This paper focuses on the study of the interaction/binding of TPPo with different model biomolecules that may favor the type-I mechanism in the overall photodynamic process, including nucleosides, proteins, and phospholipids. Compared with more hydrophilic photosensitizers, it is concluded that TPPo is more likely to undergo type-II (singlet oxygen) than type-I (electron transfer) photodynamic processes in biological environments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae32e1684b406f99ac4702c9c32d97ba https://doi.org/10.1142/s1088424609000103 Zobrazit plný text záznamu