| Autor: |
Robert D. Martin, John H. Zhang, Lillian K. Lee, Nikan H. Khatibi, Yilin Zhou, Gary Stier, Richard Lee Applegate, Wanqiu Chen, William B. Rolland, Nancy Fathali |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Intracerebral Hemorrhage Research ISBN: 9783709106921 |
| DOI: |
10.1007/978-3-7091-0693-8_35 |
| Popis: |
Cerebral hypoxia-ischemia (HI) is an important cause of mortality and disability in newborns. It is a result of insufficient oxygen and glucose circulation to the brain, initiating long-term cerebral damage and cell death. Emerging evidence suggests that endothelin receptor-A (ETA) activation can play an important role in mediating brain damage. In this study, we investigated the role of ETA receptor inhibition using ABT-627 in neonatal HI injured rats. Postnatal day 10 Sprague-Dawley rat pups (n = 91) were assigned to the following groups: sham (n = 28), HI (vehicle, n = 32), and HI with ABT-627 at 3 mg/kg (n = 31). The Rice-Vannucci model was used to induce ischemia by ligating the right common carotid artery, followed by a 2 h hypoxic episode using 8% oxygen in a 37°C chamber. Postoperative assessment was conducted at 48 h after injury and again at 4 weeks. At the acute time point, investigative markers included cerebral edema, infarction volume, and body weight change. Neurobehavioral testing was measured at 4 weeks post-injury. Our findings indicated that ABT-627 had no effect on the measured parameters. This study suggests that ETA receptor blockade using ABT-627 post-treatment fails to improve neurological outcomes in neonatal HI injured rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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