Can we predict amyloid deposition by objective cognition and regional cerebral blood flow in patients with subjective cognitive decline?

Autor:	Kei Funaki, Hajime Tabuchi, Masahiro Jinzaki, Masaru Mimura, Koji Murakami, Takahito Yoshizaki, Yoshihiro Noda, Tadaki Nakahara, Daisuke Ito, Bun Yamagata, Masashi Kameyama, Shinichiro Nakajima, Taisei Wake
Rok vydání:	2019
Předmět:	medicine.medical_specialty 030214 geriatrics business.industry Neuropsychology Wechsler Adult Intelligence Scale Cognition 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Spect imaging Internal medicine medicine Anxiety Apathy Geriatrics and Gerontology medicine.symptom Cognitive decline business Gerontology Florbetaben 030217 neurology & neurosurgery
Zdroj:	Psychogeriatrics. 19:325-332
ISSN:	1346-3500
DOI:	10.1111/psyg.12397
Popis:	Background Subjective cognitive decline (SCD) may herald the first symptoms of Alzheimer's disease (AD) whereas individuals with beta-amyloid (Aβ) deposition are regarded as a high-risk group for AD. Recently, amyloid positron emission tomography (PET) studies have demonstrated clinical and cognitive feature differences between Aβ-positive and negative SCD, but details of their differences remain unclear. We aimed to investigate the relationships among Aβ deposition, clinical, and cognitive features in patients with SCD. Methods Forty-two patients with SCD (22 women, 74.5 ± 4.7 years) were examined using fluorine-18 florbetaben PET and were divided into Aβ-positive (n = 10) and negative (n = 32) groups. We compared cognitive and psychological outcomes, and single photon emission computed tomography (SPECT) imaging data between the two groups. In addition, a linear regression analysis was performed to assess relationships between the severity of SCD and neuropsychological tests, affective scores, and demographic factors. Results The rate of score changes from the immediate recall to delayed recall in the logical memory subtest of the Wechsler's Memory Scale Revised were different between the groups (P = 0.04). However, the binary logistic regression analysis showed no significant differences between the two. In addition, the severity of SCD was significantly strong in women (P = 0.002). Furthermore, within the Aβ-negative group, subjective memory loss correlated with word fluency category score (P = 0.023) and apathy scale (P = 0.037). Conclusions No significant differences were observed between Aβ-positive and -negative SCD on any of the neuropsychological measures, clinical measures, or SPECT imaging. Further, the severity of SCD was not predicted by the symptoms of anxiety, depression, or neuropsychological examination.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae2d289b6c1f63adff1d02aa644d3564 https://doi.org/10.1111/psyg.12397 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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