Early Detection of Perinatal Human Immunodeficiency Virus (HIV) Type 1 Infection Using HIV RNA Amplification and Detection
| Autor: | Mahrukh Bamji, Marcia L. Kalish, Elaine J. Abrams, Donald M. Thea, Teresa M. Brown, Jennifer Rapier, Genevieve Lambert, Richard W. Steketee, Sherry Orloff, Jeremy Weedon, Ellie E. Schoenbaum |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
biology DNA polymerase virus diseases RNA medicine.disease biology.organism_classification Virology Virus law.invention Infectious Diseases Acquired immunodeficiency syndrome (AIDS) law Immunology medicine biology.protein Immunology and Allergy Neonatology Viral disease Sida Polymerase chain reaction |
| Zdroj: | Journal of Infectious Diseases. 175:707-711 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Early diagnosis of perinatally transmitted human immunodeficiency virus type 1 (HIV) infection can guide early interventions. HIV coculture and DNA polymerase chain reaction (DNA-PCR) detect few HIV-infected infants at birth and 90%-100% by age 3 months. Because extracellular HIV RNA may appear soon after infection, a plasma HIV RNA assay was compared with DNA PCR for early detection of perinatally infected infants. Blood-draw specimens (108) obtained at the same time from 49 HIV-infected infants and 10 specimens from 8 uninfected infants were tested. HIV RNA and DNA-PCR positivity rates were 56% and 33%, respectively, in 36 specimens from 36 infants |
| Databáze: | OpenAIRE |
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