| Popis: |
Tumor cell death is the final goal of both radio- and chemotherapy. For several decades, apoptosis has been considered as the principal type of programmed cell death (PCD) in mammalian tissues. Resistance to apoptosis was closely linked to tumorigenesis, and has taken a central position in cell death research. However, in the last years it has become evident that radiotherapy as well as other therapeutic agents, including temozolomide (TMZ) are able to elicit non-apoptotic pathways of PCD, which are not always mutually exclusive, as thought in the past.In this chapter we will address this topic, focusing on apoptosis and autophagy-related cell death in cancer, their induction by IR and TMZ, and implication in glioblastoma (GB) treatment.We will review currently known mechanisms of both IR and TMZ in inducing cell death, the possibility to modulate PCD as well as other approaches which will open new perspectives for improving the efficacy of therapy in GB. |
