Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

Autor: M.C. Berkhout, Harry G.M. Heijerman, Ralph C. Aalbers, Cornelis J. van Rooden, W. J. Fokkens, E. Rijntjes, Lahssan H. el Bouazzaoui
Rok vydání: 2014
Předmět:
Zdroj: The Laryngoscope. 124:1682-1686
ISSN: 0023-852X
DOI: 10.1002/lary.24575
Popis: Objectives/Hypothesis Paranasal sinus pneumatization in patients with cystic fibrosis (CF) is less extensive compared to the general population and seems to be correlated to CF genotype. Interestingly, in CF patients temporal bone pneumatization (TBP) is more extensive compared to the general population, and middle ear pathology is generally uncommon in CF. It is debated whether TBP is influenced environmentally or genetically. The aim of the present study was to investigate pneumatization of the temporal bone in patients with CF and to correlate this with genotype and paranasal sinus volume. Study Design Prospective collection of data. Methods In 104 adult CF patients, computed tomography of the temporal bone and the paranasal sinuses was performed. TBP was graded using a validated scoring system. Patients were divided into two groups, mild and severe CF, based on their mutations in the CF transmembrane conductance regulator gene. Results Of the 31 patients with mild CF, 71% had extensive TBP, and of the 73 patients with severe CF, 82% had extensive pneumatization of the temporal bone. TBP did not differ significantly for CF genotype, and TBP was not correlated to paranasal sinus volume. Conclusions Whereas paranasal sinus pneumatization in CF patients seems to be related to CF genotype among other influencing factors, this study showed no correlation between TBP and CF genotype. TBP was not correlated to paranasal sinus volume. Hypothetically, in CF, pneumatization of the temporal bone is under a different influence than paranasal sinus pneumatization. Level of Evidence 4 Laryngoscope, 124:1682–1686, 2014
Databáze: OpenAIRE
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