Anti‐isthmus autoimmunity in a novel feline acquired alopecia resembling pseudopelade of humans*

Autor: Thierry Olivry, Desmond J. Tobin, Peter F Moore, Helen T. Power, Jennifer C. Woo
Rok vydání: 2000
Předmět:
Zdroj: Veterinary Dermatology. 11:261-270
ISSN: 1365-3164
0959-4493
Popis: Pseudopelade is a primary scarring (cicatricial) alopecia of humans characterized by lymphocyte-rich inflammation centred around the hair follicle isthmus. Lymphocyte folliculotropism is associated with isthmus apoptosis and, ultimately, follicular destruction and dermal fibrosis. In a cat, an acquired alopecia was diagnosed as pseudopelade based on the following criteria: (i) an adult-onset, patchy to diffuse nonpruritic hair loss; (ii) an early folliculo-destructive phase in which lymphocytes and dendritic cells accumulated in and around the follicular isthmus; and (iii) a late stage in which the lower segments of hair follicles underwent atrophy and were replaced by fibrosing tracts. Additionally, immunological investigations characterized the cytotoxic phenotype of isthmotropic lymphocytes and demonstrated the presence of circulating IgG autoantibodies specific for multiple follicular antigens. Altogether, the results of the present study suggest an immune-mediated pathogenesis for this case of feline pseudopelade, similarly to that causing alopecia areata in humans and other mammalian species.
Databáze: OpenAIRE
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