Peculiarities of insulin resistance syndrome in non-alcoholic steatogepatitis on the background of type 2 diabetes mellitus depending on the stage of diabetic kidney disease
| Autor: | O. S. Khukhlina, Z. Ya. Kotsiubiichuk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Insulin medicine.medical_treatment Type 2 Diabetes Mellitus Renal function Type 2 diabetes medicine.disease Gastroenterology Insulin resistance Diabetes mellitus Internal medicine medicine Hyperinsulinemia Albuminuria General Earth and Planetary Sciences medicine.symptom business General Environmental Science |
| Zdroj: | Bukovinian Medical Herald. 24:134-142 |
| ISSN: | 2413-0737 1684-7903 |
| Popis: | To study the interaction of changes in glucose and insulin homeostasis, the degree of IR and insulin sensitivity, the degree of glycosylation of hemoglobin on the clinical course of NASH on the background of diabetes mellitus depending on the presence of DKD and its stage.Material and methods. 108 patients with NASH with comorbid diabetes were examined. The average age of patients was (58.2 ± 6.1) years. There were 63 women (58.3%) and 45 men (41.7%). Depending on the presence of DKD, 4 groups of patients were formed, which were randomized by age, sex, activity of cytolytic syndrome of NASH depending on the stage of DKD. The comparison group consisted of 30 healthy individuals (PHP) of the appropriate age and sex. The degree of hepatic steatosis and its nature were determined using a ratified kit "SteatoTest", "ASH" and "NASH-Test" (BioPredictive, France) in the laboratory Sinevo. The stage of liver fibrosis was determined by using a set of markers for quantitative biochemical evaluation of fibrosis "FibroTest" (BioPredictive, France) in the laboratory Sinevo. Calculation of the glomerular filtration rate (GFR) was performed using a GFR calculator of the Institute of Nephrology of the National Academy of Medical Sciences of Ukraine on the average of three calculated indicators: creatinine clearance according to the Cockcroft-Golt formula, MDRD and CKD EPI. Determination of the stages of DKD was carried out according to the classification of C.E. Mogensen (1983).Results. In patients with NASH, diabetes mellitus and DKD I-II st. found a probable decrease in the content of albumin in the blood by 9.0% (p |
| Databáze: | OpenAIRE |
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