Preparation of aromatic γ-hydroxyketones by means of Heck coupling of aryl halides and 2,3-dihydrofuran, catalyzed by a palladium(ii) glycine complex under microwave irradiation

Autor:	Ramón Guzmán-Mejía, Omar Sánchez-Antonio, Judit A. Aviña-Verduzco, Marco A. García-Revilla, J. Betzabe González-Campos, Eusebio Juaristi, Juan C. Jiménez-Cruz
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Ketone Aryl Halide chemistry.chemical_element General Chemistry Tautomer Catalysis chemistry.chemical_compound chemistry Heck reaction Polymer chemistry Materials Chemistry 2 3-Dihydrofuran Palladium
Zdroj:	New Journal of Chemistry. 44:13382-13392
ISSN:	1369-9261 1144-0546
DOI:	10.1039/d0nj02630a
Popis:	A series of aromatic γ-hydroxyketones were prepared by means of Heck coupling reaction of aryl halides and 2,3-dihydrofuran, catalyzed by PdCl2·Gly2 and under microwave irradiation. This synthetic transformation involves the formation of an aryl-dihydrofuranoic intermediate, followed by an unusual opening of the heterocycle promoted by a water molecule and the formation of the ketone carbonyl function through keto–enol tautomerism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ae000c34bfc9c0b529a597da286c35e0 https://doi.org/10.1039/d0nj02630a Zobrazit plný text záznamu