Hematopoietic Bone Marrow Cells of Rat after Intravenous Administration of Chitosan-Modified Magnetite Nanoparticles
| Autor: | I. V. Mil’to, O. N. Serebryakova, I. V. Sukhodolo, R. M. Takhauov, N. M. Shevtsova, V. V. Ivanova |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
030102 biochemistry & molecular biology Cell Biology Single injection Rat Bone Marrow Biology Molecular biology Chitosan 03 medical and health sciences chemistry.chemical_compound Haematopoiesis Magnetite Nanoparticles 030104 developmental biology medicine.anatomical_structure chemistry Normoblast medicine Magnetic nanoparticles Bone marrow |
| Zdroj: | Cell and Tissue Biology. 15:67-76 |
| ISSN: | 1990-5203 1990-519X |
| DOI: | 10.1134/s1990519x21010090 |
| Popis: | Chitosan-modified magnetic nanoparticles are a promising basis for the creation of new diagnostic agents and therapeutic drugs. The cells of erythroid, granulocytic, monocytic, lymphocytic, and megakaryocytic lineages of bone marrow of mature rats were investigated for 120 days after single injection of 0.14 g per 1 kg body weight chitosan-modified magnetic nanoparticles (Fe3O4). Light microscopy was applied to describe the structure of hematopoietic cells and morphometric study was performed on Romanowsky—Giemsa stained smears to measure cells size (µm) and relative number (%). Comparison of the biological effects of nonmodified and modified magnetite nanoparticles on hematopoietic cells of bone marrow revealed the advantages of modification. Chitosan-modified magnetite nanoparticles did not affect the structure of hematopoietic cells in the rat bone marrow, and their injection produced a reversible increase in the relative number of monocytes, stab neutrophils and segmented neutrophils, as well as polychromatic and oxyphilic normoblasts. |
| Databáze: | OpenAIRE |
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