| Autor: |
Lech B. Dobrzański, Anna D. Dobrzańska-Danikiewicz, L. A. Dobrzański, Piotr Malara, Marek Szindler, A. Achtelik-Franczak, L. Kroll, Zenon P. Czuba |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Archives of Materials Science and Engineering. 2:53-85 |
| ISSN: |
1897-2764 |
| Popis: |
Purpose: The article concerns the development of completely new groups of composite materials that can be used to produce functional replacements for damaged bones or teeth. Design/methodology/approach: A selective laser sintering was used to produce the reinforcement of those materials from titanium and its Ti6Al4V alloy in the form of skeletons with pores with adjustable geometric features. The matrix of those materials is either air or crystallised from the liquid AlSi12 or AlSi7Mg0.3 alloys condition after prior vacuum infiltration or human osteoblast cells from the hFOB 1.19 (Human ATCC - CRL - 11372) culture line. Findings: The porous material may be used for the non-biodegradable scaffold. After implantation into the body in the form of an implant-scaffold one, it allows the natural cells of the patient to grow into the pores of the implant, and it fuses with the bone or the appropriate tissue over time. The essential part of the implant-scaffold is the porous part inseparably connected with the core of solid materials. Into pores can grow living cells. Research limitations/implications: Biological-engineering composite materials in which natural cells were cultured in the pores in the laboratory next are combined as an artificial material with the natural cells of the patient in his/her body. Practical implications: The hybrid technologies of the all group of those materials were obtained and optimised. Numerous structure research was carried out using the most modern research methods of contemporary materials engineering, and mechanical tests and biological research involving the cultivation of natural cells were realised. Originality/value: The results of the research indicate the accuracy of the idea of implementing a new group of biological-engineering materials and the wide possibilities of their application in regenerative medicine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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