Polymorphisms in the renin-angiotensin system and endothelium-dependent vasodilation in normotensive subjects
| Autor: | Håkan Melhus, Lisa Kurland, Jonas Millgård, Sverker Ljunghall, Lars Lind, Mahziar Sarabi |
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| Rok vydání: | 2001 |
| Předmět: |
Aldosterone synthase
medicine.medical_specialty Angiotensin II receptor type 1 Endothelium biology Physiology Vasodilation medicine.anatomical_structure Endocrinology Internal medicine medicine.artery Genotype Renin–angiotensin system medicine biology.protein Sodium nitroprusside Brachial artery medicine.drug |
| Zdroj: | Clinical Physiology. 21:343-349 |
| ISSN: | 0144-5979 |
| DOI: | 10.1046/j.1365-2281.2001.00336.x |
| Popis: | Background Our aim was to test the hypothesis that genes encoding components in the renin–angiotensin system influence endothelial vasodilatory function. Methods In 59 apparently healthy, normotensive individuals, endothelium-dependent vasodilation (EDV) and endothelial-independent vasodilation (EIDV) was evaluated by infusing metacholine and sodium nitroprusside into the brachial artery. Forearm blood flow was measured by venous occlusion plethysmography. The ACE insertion (I)/deletion (D) polymorphism, the T174M and M235T angiotensinogen restriction fragments length polymorphisms, the angiotensin II receptor type 1 (AT1R) A1166C, and the aldosterone synthase gene (CYP11B2) C-344T polymorphisms were analysed. Results When analysing the ACE, the two angiotensinogen and the aldosterone synthase CYP11B2 genotypes independently, no significant association with endothelial vasodilatory function was found. However, a significant reduction in endothelium-dependent vasodilation was observed in the subjects (n=9) with the ACE D allele and the angiotensinogen T174M genotype (P |
| Databáze: | OpenAIRE |
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