Solid State Fermentation Optimization of Pleurotus Ostreatus for Lovastatin Production
| Autor: | Musa Şőlener, Mustafa Yamaç, Zeki Yildiz, Burcu Atli |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
biology 010405 organic chemistry Chemistry food and beverages Reductase biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Solid-state fermentation Drug Discovery medicine Red yeast rice Yeast extract Particle size Response surface methodology Lovastatin Pleurotus ostreatus Food science medicine.drug |
| Zdroj: | Pharmaceutical Chemistry Journal. 53:858-864 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | The present study was aimed at optimization of the solid state fermentation of lovastatin (HMG-CoA reductase inhibitor) using the Plackett – Burman (PB) design and response surface methodology (RSM) for edible and medicinal mushroom Pleurotus ostreatus so as to improve Pleurotus-fermented products (like red yeast rice) with health promoting properties. According to the results of PB design, the barley, yeast extract, and particle size of the solid substrate were found to have significant effect on lovastatin production. The concentrations of barley and yeast extract and the particle size of the solid substrate were further optimized by RSM. As a result, high lovastatin production (34.97 mg/g) was achieved at the optimized conditions of barley (8 g), yeast extract (1% w/w), and particle size of the solid substrate (0.5 - 1 mm) at 28°C for 6 days. |
| Databáze: | OpenAIRE |
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