Afferent-inherent regulation of myosin heavy chain isoforms in rat muscle spindles
| Autor: | Jun Wang, Jon M. Walro, Gina M. Story |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Denervation
medicine.medical_specialty animal structures Physiology Muscle spindle Hindlimb Biology musculoskeletal system Sensory receptor medicine.disease Spinal cord Muscle hypertrophy Cellular and Molecular Neuroscience medicine.anatomical_structure Endocrinology Atrophy Physiology (medical) Internal medicine Myosin medicine Neurology (clinical) |
| Zdroj: | Muscle & Nerve. 20:1549-1560 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/(sici)1097-4598(199712)20:12<1549::aid-mus10>3.0.co;2-w |
| Popis: | Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by comparing myosin heavy chain (MHC) expression in intrafusal fibers after ablation of afferents (deafferentation, or DA) to the extensor digitorum longus (EDL) of adult rats or after ablation of the corresponding central processes of afferents to the spinal cord (central-process ablation, or CPA). DA and CPA elicited an exaggerated pedal plantarflexion, and hypertrophy of the EDL concomitant with atrophy of the soleus in the affected hindlimb. Frequencies and patterns of expression of seven MHCs expressed by intrafusal fibers in CPA muscles were indistinguishable from normal rats. However, frequencies and patterns of expression of several MHCs were abnormal following DA. Thus factors transported anterogradely from afferents to intrafusal fibers may regulate MHC expression in intrafusal fibers. |
| Databáze: | OpenAIRE |
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