Hepatoprotective Properties of Native Humic Acids Isolated from Lowland Peat of Tomsk Region

Autor:	R. R. Akhmedzhanov, A. M. Gur’ev, M. V. Belousov, Mekhman S. Yusubov, M. V. Zykova
Rok vydání:	2014
Předmět:	Pharmacology Peat Antioxidant Chemistry medicine.medical_treatment Pharmacology toxicology CCL4 medicine.anatomical_structure stomatognathic system Biochemistry Excretory system Rat liver Hepatocyte Drug Discovery Botany medicine
Zdroj:	Pharmaceutical Chemistry Journal. 48:249-252
ISSN:	1573-9031 0091-150X
Popis:	The hepatoprotective properties of humic acids from lowland peat of Tomsk region were studied experimentally. It was established that native humic acids of peat (HAP) exhibited pronounced hepatoprotective activity against acute CCl4 hepatitis. The results showed that intragastric injection of HAP prevented damage from CCl4 to the metabolic and morphologic parameters of rat liver. The rates of lipoxidation and destruction of hepatocyte membranes and the manifestation of cytolytic syndrome decreased substantially. Liver excretory function improved. Fibrous structures did not develop in livers of experimental animals. The hepatoprotective action of HAP may be due to their pronounced antioxidant properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::aded8bf2a5352c06fce7388dc0be762e https://doi.org/10.1007/s11094-014-1088-5 Zobrazit plný text záznamu Plný text ve formátu PDF