ChemInform Abstract: ANALOGS OF PYRIMIDINE NUCLEOSIDES. 14. SYNTHESIS AND ANTINEOPLASTIC ACTIVITY OF ALKOXYALKYL DERIVATIVES OF 5-FLUOROURACIL

Autor:	A. S. Tsieminya, S. M. Mikhailov, M. Ya. Karpeiskii, A. A. Ziderman, I. M. Kravchenko, M. Yu. Lidak, R. A. Zhuk
Rok vydání:	1981
Předmět:	NMR spectra database chemistry.chemical_compound Trimethylsilyl Pyrimidine Fluorouracil Chemistry medicine General Medicine Alkylation Medicinal chemistry digestive system diseases medicine.drug
Zdroj:	Chemischer Informationsdienst. 12
ISSN:	0009-2975
Popis:	A number of alkoxyalkyl derivatives of 5-fluorouracil were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with α-chloro ethers or by the addition of 5-fluorouracil to vinyl ethers. It was established that the synthesized compounds are capable of increasing the lifetimes of mice with L-1210 leukemia and La hemocytoblastosis. The UV and NMR spectra of the synthesized compounds are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::add373190f4af593f412708d935d6429 https://doi.org/10.1002/chin.198114250 Zobrazit plný text záznamu Plný text