Distinct gene expression profiles in peripheral blood mononuclear cells from patients infected with vaccinia virus, yellow fever 17D virus, or upper respiratory infections
| Autor: | Kathryn V. Steiger, N. Jean Haulman, Christine M. Caputo, Douglas G. Miner, Christine Pilar, Jack T. Stapleton, Donna Klinzman, Charles L. Magness, Martha H. Gillham, Janice McKee, Patricia A. Ward, Patricia L. Winokur, Nicholas D. Poitinger, Christina A. Scherer, Shawn P. Iadonato |
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| Rok vydání: | 2007 |
| Předmět: |
Regulation of gene expression
General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Respiratory infection Yellow fever vaccine Biology Virology Peripheral blood mononuclear cell Virus Gene expression profiling chemistry.chemical_compound Infectious Diseases chemistry Interferon medicine Molecular Medicine Vaccinia medicine.drug |
| Zdroj: | Vaccine. 25:6458-6473 |
| ISSN: | 0264-410X |
| Popis: | Gene expression in human peripheral blood mononuclear cells was systematically evaluated following smallpox and yellow fever vaccination, and naturally occurring upper respiratory infection (URI). All three infections were characterized by the induction of many interferon stimulated genes, as well as enhanced expression of genes involved in proteolysis and antigen presentation. Vaccinia infection was also characterized by a distinct expression signature composed of up-regulation of monocyte response genes, with repression of genes expressed by B and T-cells. In contrast, the yellow fever host response was characterized by a suppression of ribosomal and translation factors, distinguishing this infection from vaccinia and URI. No significant URI-specific signature was observed, perhaps reflecting greater heterogeneity in the study population and etiological agents. Taken together, these data suggest that specific host gene expression signatures may be identified that distinguish one or a small number of virus agents. |
| Databáze: | OpenAIRE |
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