| Autor: |
Nancy E. Maestri, Bart Kiemeney, Deborah A. Meyers, Jianfeng Xu, Michele C. LaBuda, Valerie L. Prenger, Carolien I.M. Panhuysen, Rebecca Koskela, Eugene W. Taylor |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Genetic Epidemiology. 12:825-830 |
| ISSN: |
0741-0395 |
| DOI: |
10.1002/gepi.1370120649 |
| Popis: |
A two-locus segregation and linkage-analysis approach was used to characterize the genetic control of a complex trait (Q1) and to localize the genes that have detectable effects. The results suggested that a two-locus Mendelian model fit the data significantly better than a one-locus model. The linkage results based on the most parsimonious two-locus model revealed linkage of Q1 to two areas (MG2 and MG3), while there was less evidence for linkage using one-locus models. Results also suggested that the subphenotypes (Q2 and Q3) provided useful information for further analysis of Q1 using two-locus models. © 1995 Wiley-Liss, Inc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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