Effect of phosphocreatine on reflex activity of the brain stem reticular formation

Autor:	Gokin Ap, Yu. P. Limansky, M. V. Karpukhina
Rok vydání:	1994
Předmět:	Physiology Chemistry General Neuroscience Anatomy Reticular formation Fourth ventricle Phosphocreatine chemistry.chemical_compound medicine.anatomical_structure Reticular connective tissue Reflex medicine Inhibitory effect Nucleus Volume concentration
Zdroj:	Neurophysiology. 25:228-232
ISSN:	1573-9007 0090-2977
DOI:	10.1007/bf01054508
Popis:	The effects of phosphocreatine (PCr) on startle reflexes, known to be relayed through the brain stem reticular formation (RF), were investigated on chloralose-anesthetized rats. PCr (10−6 to 10−3 M) was either applied superficially to the bottom of the fourth ventricle or microinjected into the reticular gigantocellular nucleus. The PCr effect was found to depend on its concentration. At low concentrations (10−6 to 10−5 M), PCr markedly facilitated the reflexes; sometimes its application gave rise to additional, later and longer, discharges following startle reflexes, whereas an inhibitory effect predominated at higher PCr concentration (10−4 to 10−3 M). Possible mechanisms of PCr action on the studied reflexes are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::adc03f40814b39ce913e537864744b1b https://doi.org/10.1007/bf01054508 Zobrazit plný text záznamu Full text from SpringerLink