Facile Fabrication of Biocompatible Gelatin-Based Self-Healing Hydrogels
| Autor: | Changdao Mu, Xinying Li, Jinfeng Lei, Shen Wang, Lun Yuan, Liming Ge, Defu Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Schiff base Polymers and Plastics Biocompatibility Process Chemistry and Technology Organic Chemistry Imine technology industry and agriculture macromolecular substances complex mixtures Gelatin Carboxymethyl cellulose chemistry.chemical_compound food Chemical engineering chemistry Covalent bond Self-healing hydrogels medicine Macromolecule medicine.drug |
| Zdroj: | ACS Applied Polymer Materials. 1:1350-1358 |
| ISSN: | 2637-6105 |
| Popis: | The self-healing hydrogels are extremely attractive in biological and biomedical fields. The imine bond obtained by the Schiff base reaction is a commonly used dynamic covalent bond to fabricate self-healing hydrogels. Gelatin is a commonly used natural macromolecule in the biomedical field with excellent biocompatibility, biodegradability, and nonimmunogenicity. However, the gelatin-based hydrogels with self-healing ability are rarely reported based on imine bonds. Herein, we present a facile approach to fabricate a gelatin hydrogel with self-healing ability based on the Schiff base reaction. The gelatin was first reacted with ethylenediamine to increase the content of amino groups. Then dialdehyde carboxymethyl cellulose was used to cross-link amino-gelatin to fabricate the self-healing hydrogel. The results showed that the fabricated hydrogel exhibited good self-healing ability as expected because of the formed dynamic imine bonds between amino-gelatin and dialdehyde carboxymethyl cellulose. The hydrog... |
| Databáze: | OpenAIRE |
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