Automatic wavelet-based assessment of behavioral sleep using multichannel electrocorticography in rats

Autor: Anton R. Kiselev, Kirill Smirnov, Evgenia Sitnikova, Anatoly S. Karavaev, Maksim O. Zhuravlev, Rodion Ukolov, Anastasiya E. Runnova
Rok vydání: 2021
Předmět:
Zdroj: Sleep and Breathing. 25:2251-2258
ISSN: 1522-1709
1520-9512
Popis: During the last decade, the reported prevalence of sleep-disordered breathing in adults has been rapidly increasing. Therefore, automatic methods of sleep assessment are of particular interest. In a framework of translational neuroscience, this study introduces a reliable automatic detection system of behavioral sleep in laboratory rats based on the signal recorded at the cortical surface without requiring electromyography. Experimental data were obtained in 16 adult male WAG/Rij rats at the age of 9 months. Electrocorticographic signals (ECoG) were recorded in freely moving rats during the entire day (22.5 ± 2.2 h). Automatic wavelet-based assessment of behavioral sleep (BS) was proposed. The performance of this wavelet-based method was validated in a group of rats with genetic predisposition to absence epilepsy (n=16) based on visual analysis of their behavior in simultaneously recorded video. The accuracy of automatic sleep detection was 98% over a 24-h period. An automatic BS assessment method can be adjusted for detecting short arousals during sleep (microarousals) with various duration. These findings suggest that automatic wavelet-based assessment of behavioral sleep can be used for assessment of sleep quality. Current analysis indicates a temporal relationship between microarousals, sleep, and epileptic discharges in genetically prone subjects.
Databáze: OpenAIRE
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