Sexual dimorphism modulates brain histamine functions at multiple sites
| Autor: | P. Portaleone, T. Adage, Marinella Blengio, Carlo Ferretti, Piera Ghi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Agonist medicine.medical_specialty medicine.drug_class medicine.medical_treatment Immunology Histaminergic Biology Toxicology Steroid Sexual dimorphism chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Pharmacology (medical) Binding site Histamine H3 receptor Receptor Histamine |
| Zdroj: | Agents and Actions. 36:C336-C338 |
| ISSN: | 1420-908X 0065-4299 |
| Popis: | Sexual dimorphism has been demonstrated in rat brain and the ovarian steroids affect H1 and H2 histaminergic binding sites as demonstrated with [3H]-mepyramine and [3H]-histamine, respectively. The evaluation of histamine release, related to the presynaptic H3 receptors, from cortical slice preparations reveals hyposensitive releasing activity in the female rat compared to the male, both after KCl-induced histamine release and after inhibition of histamine release by (R)α-methylhistamine (H3 selective agonist). Therefore, we may suggest a global hyposensitivity of the histaminergic neural system in female rats under the modulation of ovarian sexual steroids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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