Program extracorporeal photophoresis in complex treatment of psoriatic arthritis
| Autor: | A S Manuilov, A S Trulev, S N Bardakov, A A Sokolov, E. V. Sherbakov, M V Zakharov, A V Apchel, M K Serebriakova, T. S Ryabova, A. N. Belskykh, Igor Kudryavtsev, K. Yu Volkov, V V Tishko |
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| Rok vydání: | 2020 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty Cellular immunity medicine.diagnostic_test business.industry 030204 cardiovascular system & hematology medicine.disease Gastroenterology 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Immune system Internal medicine Erythrocyte sedimentation rate Extracorporeal Photopheresis medicine Methotrexate In patient business medicine.drug Extracorporeal Photophoresis |
| Zdroj: | Bulletin of the Russian Military Medical Academy. 22:95-99 |
| ISSN: | 2687-1424 1682-7392 |
| DOI: | 10.17816/brmma25975 |
| Popis: | The results of complex treatment with the programmed procedures of extracorporeal photopheresis and methotrexate in patients with psoriatic arthritis for 12 months are presented. It has been established that program extracorporeal photopheresis in combination with basic therapy with methotrexate in patients with psoriatic arthritis have a significant effect on the relief of articular syndrome (reduction of morning stiffness, pain intensity, joint swelling). It was revealed that the inclusion of programmed extracorporeal photopheresis and methotrexate in the complex treatment of psoriatic arthritis reduces the level of circulating low molecular weight, medium molecular weight and high molecular weight immune complexes and in most cases leads to clinical and immunological remission. This is confirmed by a decrease in complaints of the severity of articular syndrome and a decrease in the clinical and laboratory activity of the disease (a significant decrease in the level of C-reactive protein, erythrocyte sedimentation rate). A scheme has been developed for the programmed use of extracorporeal photopheresis procedures in the complex treatment of psoriatic arthritis, which consists of 2 procedures every other day with an interval of 2,5-3 months for 12 months. Combined therapy with the programmed application of extracorporeal photopheresis procedures and methotrexate prolongs the period of disease remission and can be recommended for patients with psoriatic arthritis with high activity, insufficient effect of basic therapy and intolerance to higher doses of immunosuppressive drugs. |
| Databáze: | OpenAIRE |
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