Parotitis in previus recipients of mumps vaccine
| Autor: | Elaine Allen, Sharon Steinberg, Anthony Brickman, Philip A. Brunell |
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| Rok vydání: | 1971 |
| Předmět: | |
| Zdroj: | Pediatric Research. 5:403-403 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-197108000-00135 |
| Popis: | Between 1967 and 1970, twenty children with parotitis who had previously received mumps vaccine were studied. These children were immunized in four different Pediatric offices over a four year period so that no single lot of vaccine or immunizing procedure could be implicated as the cause of these apparent “vaccine failures.” Mumps soluble complement fixing (MSCF) antibody determinations revealed that only eight of the seventeen children for whom appropriate serum specimens were available had evidence of mumps infection. Children without a detectable antibody response could not be differentiated clinically from those who developed MSCF antibody. Parotitis occurred in two siblings without a MSCF antibody response suggesting that these illnesses might have an infectious etiology. Neither mumps nor any other virus could be recovered from five children without an antibody response or from three children who could not be classified serologically. These findings confirm the multiple etiology of parotitis and indicate that serologic studies are required to indentify true mumps vaccine failures. |
| Databáze: | OpenAIRE |
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