Curcumin loaded on pullulan acetate nanoparticles protects the liver from damage induced by DEN
| Autor: | Lonchin Suguna, Muthaiya Kannappan Subamekala, Thangavel Ponrasu, Moorthy Ganeshkumar, Murthy Janani |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Antioxidant 010304 chemical physics General Chemical Engineering medicine.medical_treatment Nanoparticle Pullulan 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology 01 natural sciences Bioavailability chemistry.chemical_compound chemistry Biochemistry 0103 physical sciences Drug delivery Curcumin medicine Solubility 0210 nano-technology Nuclear chemistry |
| Zdroj: | RSC Advances. 6:5599-5610 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c5ra18989f |
| Popis: | In recent years, nanoparticle based drug delivery has been used to treat liver diseases. Even though curcumin is a potent antioxidant, reactive oxygen species (ROS) scavenger and anti-inflammatory agent, its use at a clinical level is very limited due to its poor bioavailability rendered by its physiochemical properties. In this study, biodegradable liver specific pullulan acetate nanoparticles (PA) loaded with curcumin were developed for the first time. These curcumin loaded PA nanoparticles were found to improve the encapsulation efficiency and stability of curcumin with sustained release, under physiological conditions. Thus, curcumin loaded pullulan acetate nanoparticles (PAC) could solve the physicochemical defects of curcumin like solubility, pH stability, photo-stability, and be used as an effective hepato-protective agent against diethyl nitrosamine (DEN) induced liver damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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