The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients
| Autor: | Torsten E. Reichert, I Ugele, Rosemarie Krupar, Peter J. Siska, Katrin Singer, Felix Nieberle, Katrin Peter, Michael Gerken, Almut Brand, Philipp Beckhove, Gerrit Spanier, Steffen Spoerl, Marina Kreutz, Petra Rümmele, Johannes K. Meier, Kathrin Renner, Sandra Schmidhofer, L Symeou |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Internal medicine Diabetes mellitus Lactate dehydrogenase medicine Monocarboxylate transporter Tissue microarray biology business.industry Glucose transporter medicine.disease 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis biology.protein Immunohistochemistry business Infiltration (medical) |
| Zdroj: | Cancer Letters. 499:209-219 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2020.11.029 |
| Popis: | Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers such as lactate dehydrogenase (LDH) A or monocarboxylate transporter (MCT) 1 were increased in tumor samples from patients with diabetes and these patients had a significantly worse prognosis compared to non-diabetic patients. Analyses of immune cell infiltration in tumors from diabetic and non-diabetic patients revealed an increased leukocyte (CD45+) infiltration compared to normal mucosa only in non-diabetic patients. In line, the amount of CD3+ T cells per mm2 tumor tissue, was elevated in patients without diabetes and crucial for patient outcome in OSCC patients without diabetes, as compared to healthy mucosa using fluorescence immunohistochemistry in tissue microarrays of 229 patients. Our results demonstrate that diabetes is a prognostic factor for OSCC patients and associates with decreased leukocyte and CD3+ infiltration indicating that metabolic differences between diabetic and non-diabetic patients may alter tumor-infiltrating T cells and thereby determine patient outcome. |
| Databáze: | OpenAIRE |
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