| Popis: |
Epoxyalkylcopper compounds have readily been prepared by the direct oxidative addition of active copper to epoxyalkyl halides. The intramolecular cyclization of the epoxyalkylcopper reagents via an epoxide cleavage process is described. Significantly, many functional groups can be present in the bromoepoxides yielding highly functionalized carbocycles. The regioselectivity of this cyclization is affected by the connecting chain length, substitution pattern, reaction solvent, and the CuI-phosphine complex used to generate the copper. |
