Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients
| Autor: | Vincent Brandenburg, Andreas H. Mahnken, Ellen C. M. Cranenburg, Cees Vermeer, Leon J. Schurgers, Markus Ketteler, Ulrich Gladziwa, Georg Mühlenbruch, Melanie Stenger |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Pathology biology business.industry medicine.medical_treatment Hematology medicine.disease Coronary artery disease Cardiovascular calcification Calcinosis Internal medicine Rheumatoid arthritis Matrix gla protein medicine biology.protein Cardiology Biomarker (medicine) business Dialysis Calcification |
| Zdroj: | Thrombosis and Haemostasis. 101:359-366 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th08-04-0241 |
| Popis: | SummaryMatrix γ-carboxyglutamate (Gla) protein (MGP) is a potent local inhibitor of cardiovascular calcification and accumulates at areas of calcification in its uncarboxylated form (ucMGP). We previously found significantly lower circulating ucMGP levels in patients with a high vascular calcification burden. Here we report on the potential of circulating ucMGP to serve as a biomarker for vascular calcification in haemodialysis (HD) patients. Circulating ucMGP levels were measured with an ELISA-based assay in 40 HD patients who underwent multi-slice computed tomography (MSCT) scanning to quantify the extent of coronary artery calcification (CAC). The mean ucMGP level in HD patients (193 ± 65 nM) was significantly lower as compared to apparently healthy subjects of the same age (441 ± 97 nM; p < 0.001) and patients with rheumatoid arthritis (RA) without CAC (560 ± 140 nM; p < 0.001). Additionally, ucMGP levels correlated inversely with CAC scores (r = –0.41; p = 0.009), and this correlation persisted after adjustment for age, dialysis vintage and high-sensitivity C-reactive protein (hs-CRP). Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification. |
| Databáze: | OpenAIRE |
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