Biventricular Implantable Cardioverter Defibrillators Improve Survival Compared with Biventricular Pacing Alone in Patients with Severe Left Ventricular Dysfunction

Autor:	Laura VanHeel, Scott Pham, Scott Sakaguchi, Joanne Collins, David G. Benditt, Keith G. Lurie, Fei Lu, Alan X. Zhu, Cengiz Ermis
Rok vydání:	2004
Předmět:	medicine.medical_specialty Randomization Ejection fraction business.industry Mortality rate Hemodynamics Implantable defibrillator medicine.disease Log-rank test Physiology (medical) Internal medicine Heart failure medicine Cardiology Cardiology and Cardiovascular Medicine business Survival analysis
Zdroj:	Journal of Cardiovascular Electrophysiology. 15:862-866
ISSN:	1045-3873
Popis:	Introduction: Biventricular cardiac pacemakers provide important hemodynamic benefit in selected patients with heart failure and severe left ventricular (LV) dysfunction. Nevertheless, these patients remain at high mortality risk. To address this issue, we examined mortality outcome in patients with heart failure treated with biventricular pacemakers alone and those treated with biventricular implantable cardioverter defibrillators (ICDs). Methods and Results: The study population consisted of 126 consecutive patients with LV dysfunction and heart failure who received either a biventricular ICD (n = 62) or a biventricular pacemaker (n = 64) between January 1998 and December 2002. A minimum 12 months of follow-up was obtained in all survivors. ICD indications were conventional in all patients. Kaplan-Meier actuarial method and log rank statistics were used to calculate and compare survival rates in both groups. Comparison of mortality rates utilized Chi-square test. The two groups had similar clinical and demographic features, LV ejection fraction, and medication use. Average follow-up times were 13 ± 11.8 months (range 4–60) and 18 ± 13.2 months (range 0.5–53) for biventricular ICD and pacemaker groups, respectively. Overall mortality rate was significantly lower in the biventricular ICD group (13%, 8 deaths) compared to the pacemaker group (41%, 26 deaths) (P = 0.01). Further, the predominant survival benefit for ICD-treated patients becomes evident after the first 12 months of follow-up. Conclusion: The findings in this study, although necessarily limited in their interpretation by the absence of treatment randomization, suggest that biventricular ICDs offer a survival benefit compared to biventricular pacing alone. Furthermore, this benefit may be most apparent if other clinical factors do not preclude patient survival >1 year postimplant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ad9bc13ac7052366b8d12bf2a4803183 https://doi.org/10.1046/j.1540-8167.2004.04044.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.