Low testosterone accelerates vascular damage in hypertensive smokers with more than a 20-pack-year smoking history
| Autor: | N Ioakeimidis, D Terentes-Printzios, E Sigala, P Xydis, V Gardikioti, I Gourgouli, C Georgakopoulos, K Tsioufis, C Vlachopoulos |
|---|---|
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Heart Journal. 42 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/ehab724.2384 |
| Popis: | Purpose Testosterone deficiency and cigarette smoking are both associated with increased cardiovascular (CV) mortality risk. Aim of the study is to investigate the impact of low testosterone level on vascular function and structure changes related to cumulative tobacco smoke exposure in patients with arterial hypertension. Methods Indices of vascular function and structure including carotid-femoral pulse wave velocity (PWV) and carotid intima media thickness (cIMT) were measured in 263 hypertensive males divided into 4 age-matched groups according to pack-years of smoking as never smokers (0.0 pack-years), light smokers (0.1–20.0 pack-years), moderate smokers (20.1–40.0 pack-years), and heavy smokers (>40 pack-years). Plasma total testosterone (TT) levels were measured in all patients. Results PWV and cIMT progressively increased from never smokers and light smokers to moderate and heavy smokers (overall P Conclusions The deficiency in TT levels accelerates vascular wall damage of large arteries among hypertensive smokers with more than 20 pack-years tobacco exposure. Considering the predictive value of vascular biomarkers, the findings of this study imply the possibility that the measurement of baseline testosterone level could be an unfavourable marker of smoking-related cardiovascular risk among moderate and heavy smokers with arterial hypertension. Funding Acknowledgement Type of funding sources: None. TT, tobacco smoke exposure, PWV and IMT |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|