An Experimental Study of Decellularized Xenografts Implanted Into the Aortic Position with 4 Months of Follow Up
| Autor: | Ricardo Vilani, Wolfgang Konertz, Oliver Bloch, F. da Costa, Sergio Veiga Lopes, S. Yoshi, F. P. da Souza, Pascal M. Dohmen |
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| Rok vydání: | 2012 |
| Předmět: |
Aortic valve
Pathology medicine.medical_specialty Decellularization business.industry Hemodynamics Regurgitation (circulation) medicine.disease Gross examination medicine.anatomical_structure Tissue engineering medicine Immunohistochemistry Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | Journal of Clinical & Experimental Cardiology. |
| ISSN: | 2155-9880 |
| DOI: | 10.4172/2155-9880.s4-004 |
| Popis: | This study evaluated decellularized stentless porcine xenografts into the aortic position of seven juvenile sheep. The hemodynamic performance were analyzed by means of echocardiographic examination. Post mortum, specimens were evaluated by gross examination, light microscopy, and immunohistochemical staining. Explantations were performed at up to four months. Echocardiographic evaluation examination showed a maximum flow velocity of 0.94m/s with absence of regurgitation. Gross examination showed smooth and pliable leaflets endothelial cells covered the valve wall and leaflets, deeper layers presented ingrowth of host interstitial cells. There was no evidence for calcification. Our preliminary results showed excellent hemodynamics. Regeneration by host cells and absence of calcifications was observed at 4 months follow-up within the systemic circulation. |
| Databáze: | OpenAIRE |
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